Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness.

Auteur(s) :
Kremers WK., Staubo SC., Aakre JA., Vemuri P., Syrjanen JA., Mielke MM., Geda YE., Machulda MM., Knopman DS., Petersen RC., Jack CR., Roberts RO.
Date :
Juil, 2016
Source(s) :
Alzheimer’s & dementia : the journal of the Alzheimer’s Association. #: p
Adresse :
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: [email protected]

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INTRODUCTION
The Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers.

METHODS
Among 672 cognitively normal participants (mean age, 79.8 years, 52.5% men), we investigated associations of MeDi score and MeDi components with magnetic resonance imaging measures of cortical thickness for the four lobes separately and averaged (average lobar).

RESULTS
Higher MeDi score was associated with larger frontal, parietal, occipital, and average lobar cortical thickness. Higher legume and fish intakes were associated with larger cortical thickness: legumes with larger superior parietal, inferior parietal, precuneus, parietal, occipital, lingual, and fish with larger precuneus, superior parietal, posterior cingulate, parietal, and inferior parietal. Higher carbohydrate and sugar intakes were associated with lower entorhinal cortical thickness.

DISCUSSION
In this sample of elderly persons, higher adherence to MeDi was associated with larger cortical thickness. These cross-sectional findings require validation in prospective studies.

Source : Pubmed
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