Long-term diet and biomarker changes after a short-term intervention among Hispanic breast cancer survivors: The ¡Cocinar Para Su Salud! randomized controlled trial.

Auteur(s) :
Greenlee H., Hershman DL., Aycinena AC., Koch PA., Contento IR., Karmally W., Richardson JM., Lim E., Tsai WY., Maurer M., Kalinsky K., Odgen Gaffney A., Shi Z., Santella RM., Blaner WS., Clugston RD., Cremers S., Pollak S., Sirosh I., Crew KD.
Date :
Nov, 2016
Source(s) :
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. #25:11 p1491-1502
Adresse :
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York. [email protected]

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BACKGROUND
Among Hispanic breast cancer (BC) survivors, we examined the long-term effects of a short-term culturally-based dietary intervention on increasing fruits/vegetables (F/V), decreasing fat and changing biomarkers associated with BC recurrence risk.

METHODS
Spanish-speaking women (n=70) with a history of stage 0-III BC who completed treatment were randomized to ¡Cocinar Para Su Salud! (n=34), a culturally-based 9-session program (24 hours over 12 weeks, including nutrition education, cooking classes, and food-shopping field trips), or a control group (n=36, written dietary recommendations for BC survivors). Diet recalls, fasting blood, and anthropometric measures were collected at baseline, 6, and 12 months. We report changes between groups at 12 months in dietary intake and biomarkers using 2-sample Wilcoxon t-tests and Generalized Estimating Equation (GEE) models.

RESULTS
At 12 months, the intervention group compared to the control group reported higher increases in mean daily F/V servings (total: +2.0 vs. -0.4; P=0.006), and non-significant decreases in percent calories from fat (-2.2% vs. -1.1%; P=0.69) and weight (-2.6 kg vs. -1.5 kg; P=0.56). Compared to controls, participants in the intervention group had higher increases in plasma lutein (+20.4% vs. -11.5%; P=0.002), and borderline significant increases in global DNA methylation (+0.8% vs. -0.5%; P=0.06).

CONCLUSIONS
The short-term ¡Cocinar Para Su Salud! program was effective at increasing long-term F/V intake in Hispanic BC survivors and changed biomarkers associated with BC recurrence risk.

IMPACT
It is possible for short-term behavioral interventions to have long-term effects on behaviors and biomarkers in minority cancer patient populations. Results can inform future study designs.

Source : Pubmed
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